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Osteopetro-rickets : a new cogenital bone disorder

Identifieur interne : 00D722 ( Main/Exploration ); précédent : 00D721; suivant : 00D723

Osteopetro-rickets : a new cogenital bone disorder

Auteurs : G. Milhaud [France] ; M.-L. Labat [France] ; I. Litwin [France] ; Y. Moricard [France] ; R. Moutier [France] ; C. Rimbaut [France] ; D. Buffe [France] ; M. Juster [France]

Source :

Metabolic Bone Disease and Related Research [ 0221-8747 ] ; 1981.

RBID : ISTEX:F9BBB5A2AB3ABFDCADD2A71C7D658CDE59B0C7AF

English descriptors

Abstract

Abstract: Two lethal nwtations have been described in the rat: ⪡ osteopetrosis ⪢ (op) and , ⪡ toothless ⪢ (tl). The op mutant can be cured by normal bone marrow infusion, while the tl mutant cannot. We report here additional data with regard to the tl mutant. The bone disease of the tl rat as in the op rat Is associated with a ,precocious thymic atrophy, but bone lesions are quite different. In addition to classical osteopetrosis, the tl rat displays several features of rickets: broadening of the extremities of long bones, thickening of the epiphyseal plates, presence of osteoid areas. In addition, the persistence of embryonic characters, evidenced by high levels of alpha-fetoprotein, suggests that the developmental defect of bone is part of a more general process.

Url:

https://api.istex.fr/document/F9BBB5A2AB3ABFDCADD2A71C7D658CDE59B0C7AF/fulltext/pdf

DOI: 10.1016/0221-8747(81)90026-6

Affiliations:

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to stream Istex, to step Corpus: 007B64
to stream Istex, to step Curation: 007B64
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to stream Main, to step Curation: 00D722

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Two lethal nwtations have been described in the rat: ⪡ osteopetrosis ⪢ (op) and , ⪡ toothless ⪢ (tl). The op mutant can be cured by normal bone marrow infusion, while the tl mutant cannot. We report here additional data with regard to the tl mutant. The bone disease of the tl rat as in the op rat Is associated with a ,precocious thymic atrophy, but bone lesions are quite different. In addition to classical osteopetrosis, the tl rat displays several features of rickets: broadening of the extremities of long bones, thickening of the epiphyseal plates, presence of osteoid areas. In addition, the persistence of embryonic characters, evidenced by high levels of alpha-fetoprotein, suggests that the developmental defect of bone is part of a more general process.</div>
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Osteopetro-rickets : a new cogenital bone disorder

Osteopetro-rickets : a new cogenital bone disorder

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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